• The win improved the Titans' all-time record at Nissan Stadium, including playoffs, to 104-80.
• The win gave the organization an all-time record of 25-18 on Monday Night Football, including a 14-7 mark in the "Titans era" (since 1999).
• Mike Vrabel recorded his 35th win, including regular season and playoffs, since he became the team's head coach in 2018. His record is now 35-23.
• For the second consecutive season, the Titans won at least four of their first six games of the season. They were 5-1 to begin the 2020 campaign.
• The announced attendance of 69,419 set a new record for a Titans game at Nissan Stadium, which opened in 1999. The previous high was 69,363 against New England on Nov. 11, 2018.
• The Titans offense scored touchdowns on all three of the unit's trips inside the red zone against the Bills, while the Titans defense limited the Bills offense to two touchdowns on five possessions inside the 20. In those drives by the Bills, they came away with two touchdowns, two field goals and one turnover on downs, the latter of which sealed the victory for the Titans.
• The Titans offense put up 362 total yards and 146 rushing yards against a Bills defense that was ranked first overall (251.8 yards allowed per game) and third against the run (78.4) entering the contest.
• The Titans' 34 points were the most allowed in 2021 by the Bills, who had the NFL's top scoring defense entering the week (12.8 points allowed per game).
• The Titans joined the Cleveland Browns (Sept. 12 against Kansas City) as the NFL's only team with four rushing touchdowns in a game through six weeks of the 2021 season.
• Outside of the final possession of the first half and the final kneel-down possession in the fourth quarter, the Titans produced points on their final six possessions of the game-four touchdowns and two field goals.
• The defense generated a game-winning stop near the goal line in the game's final minute. Trailing by three points, the Bills faced a fourth-and-one at Tennessee's three-yard line with 22 seconds on the clock in the fourth quarter. On Josh Allen's quarterback sneak, Titans defensive tackle Jeffery Simmons penetrated and stuffed Allen for no gain, sealing the victory.
DL DENICO AUTRY
• Deflected a pass that was then intercepted by Kevin Byard in the second quarter, leading to a Titans touchdown on the subsequent drive.
WR A.J. BROWN
• Led the team with seven receptions and 91 receiving yards, all of which came in the second half.
• Converted a fourth-and-two with a 14-yard reception in the third quarter to help set up a touchdown four plays later.
K RANDY BULLOCK
• Made both field goals (43 yards in the second quarter and 38 yards in the fourth quarter) and made all four extra point attempts.
S KEVIN BYARD
• Intercepted a deflected Josh Allen pass in the second quarter and returned the ball 16 yards to Buffalo's 11-yard line to set up a Titans touchdown on the subsequent drive. He added two tackles in the contest.
• With his 21st career interception, he tied Gregg Bingham (21) for 14th place on the franchise's career interception list.
• With an interception in back-to-back games, it marked the fourth time in his career he intercepted at least one pass in consecutive contests.
• His three interceptions in the first six games of 2021 tied his career high through the first six weeks of a season (2019).
OLB BUD DUPREE
• Returned from injury and tallied two tackles and a pass defensed.
CB CALEB FARLEY
• Registered his first career start and tallied a pair of tackles.
RB DERRICK HENRY
• Rushed for 143 yards and three touchdowns on 20 carries and added two receptions for 13 yards.
• Went over the 100-yard mark on a 19-yard run in the third quarter. It marked his 28th career 100-yard rushing game, including regular season and playoffs.
• His fifth consecutive 100-yard rushing game gave him the longest streak of 100-yard games in his career (four in 2019). He tied Eddie George (1998) for the fourth-longest such streak in franchise history. The last NFL player with 100 rushing yards in five consecutive games was DeMarco Murray (eight) in 2014.
• Registered his third career 100-yard rushing game on Monday Night Football.
• Scored on a 76-yard run in the second quarter. It was the third-longest touchdown run of his career. The run was his fourth career rushing touchdown of at least 75 yards and his fifth overall touchdown of at least 75 yards (one receiving). He joined Chris Johnson (seven), Adrian Peterson (six), O.J. Simpson (five), Jamaal Charles (four), Tony Dorsett (four) and Barry Sanders (four) as the only players in NFL history with four or more rushing touchdowns of 75-plus yards.
• Added a three-yard touchdown run in the third quarter and a 13-yard touchdown run in the fourth quarter, the latter of which was the game-winning score. He became the NFL's first player since Atlanta's Devonta Freeman in 2015 with three or more rushing touchdowns in consecutive games.
• His three rushing touchdowns gave him 65 career rushing touchdowns. He passed Eddie George (64) for second place on the franchise rushing touchdowns list behind only Earl Campbell (73).
• Joined Earl Campbell as the only players in franchise history to rush for three or more touchdowns in a Monday Night Football game. Campbell did it twice-three against Pittsburgh on Oct. 23, 1978 and four against Miami on Nov. 20, 1978.
• Notched his 31st consecutive game with at least 50 rushing yards, tying Seattle's Chris Warren (1993-95) for the second-longest such streak in the NFL since 1960. Only Kansas City's Priest Holmes, with 36 consecutive 50-yard rushing games from 2001 to 2003, had a longer streak in that period than Henry.
• Joined Eric Dickerson as the NFL' s only players since 1960 with 750 rushing yards and 10 rushing touchdowns in the first six games of a season. Dickerson had 787 rushing yards and 10 rushing touchdowns in the Rams' first six games of 1983.
S AMANI HOOKER
• Returned from injured reserve to start the game and total nine tackles and a forced fumble.
WR JULIO JONES
• Totaled three receptions for 59 yards, including a 48-yard reception on a pass from Ryan Tannehill in the second quarter.
• Extended his streak to 131 consecutive individual games with at least one reception.
OLB HAROLD LANDRY III
• Totaled eight tackles, two sacks and a tackle for loss. His two sacks matched his career high.
• Ended a Bills drive with an eight-yard sack of Josh Allen in the first quarter and added a three-yard sack in the second quarter. The performance gave him 6.5 sacks in 2021 and 25.5 sacks in his career.
• Registered his fourth consecutive game with at least a half sack, his third consecutive game with at least one sack, and his second consecutive game with two sacks.
• Became Tennessee's first player since Kyle Vanden Bosch in 2005 (Sept. 18-25) with two or more sacks in consecutive games.
ILB DAVID LONG JR.
• Led the team and set a career high with 14 tackles.
DT JEFFERY SIMMONS
• Totaled five tackles, one sack and one tackle for loss.
• Sacked Josh Allen for a seven-yard loss in the fourth quarter. He improved his season total to 2.5 sacks and improved his career total to 7.5 sacks.
• Generated the game-saving tackle in the final minute of the fourth quarter. The Bills faced a fourth-and-one at Tennessee's three-yard line with 22 seconds on the clock, when Simmons tackled Josh Allen for no gain on a quarterback sneak to preserve the victory.
QB RYAN TANNEHILL
• Completed 18 of 29 passes for 216 yards with one interception and added a rushing touchdown. In the second half, he was 14-of-17 for 145 yards with no interceptions (102.2 passer rating).
• Completed a 48-yard pass to Julio Jones in the second quarter.
• Rushed for a four-yard touchdown in the second quarter. It was his second rushing touchdown of 2021 and his 19th career rushing touchdown.
• Credited with his 24th career game-winning drive and his 11th game-winning drive since joining the Titans in 2019. He completed all five of his pass attempts for 58 total yards during the go-ahead drive in the fourth quarter against the Bills.
P JOHNNY TOWNSEND
• Punted twice for a 53.5-yard average (50.5 net) with a long punt of 63 yards.
WR NICK WESTBROOK-IKHINE
• Totaled 27 yards on three receptions, all of which came during the game-winning touchdown drive in the fourth quarter.